Entropy-driven reactions in living cells for assay let-7a microRNA
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- 作者：Kai Zhang ; zhangkai@jsinm.org" class="auth_mail" title="E-mail the corresponding author ; Ke Wang ; Xue Zhu ; Minhao Xie
- 关键词：Entropy-driven ; Living cells ; miRNA ; Amplification method
- 刊名：Analytica Chimica Acta
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：949
- 期：Complete
- 页码：53-58
- 全文大小：1479 K
文摘
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An enzyme-free amplification strategy for microRNA assay is reported.
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This strategy is employed to image miRNA in single cells by using entropy-driven reaction.
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The method provides a high sensitivity with a detection limit of 0.27 pM of Let-7a.