System approach to modeling of liver glucose metabolism with physiologically interpreted model parameters outgoing from [¹⁸F]FDG concentrations measured by PET

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• 作者：Zuzana Rausova^a ; ^{zuzana.rausova@stuba.sk} ; Jana Chrenova^a ; Pirjo Nuutila^b ; Patricia Iozzo^c ; Ladislav Dedik^a
• 关键词：Liver blood flow ; Glucose metabolism ; System approach model ; Parameter estimation ; Positron emission tomography (PET) ; Physiologically interpreted parameters
• 刊名：Computer Methods and Programs in Biomedicine
• 出版年：2012
• 出版时间：August, 2012
• 年：2012
• 卷：107
• 期：2
• 页码：347-356
• 全文大小：565 K

文摘

New mathematical models from physiologically interpreted parameters capable of evaluating glucose metabolism within the liver and/or the whole body were developed.

The group of pigs in a fasting state and the group of pigs with euglycemic supraphysiological hyperinsulinemia were scanned by positron emission tomography after a single dose of [¹⁸F]FDG tracer. Simultaneously frequent sampling of the dynamic data of [¹⁸F]FDG plasma concentration in artery, portal vein and hepatic vein was obtained. A system approach to the liver and/or the whole-body system by the tools of linear dynamic sysztem theory was used.

Three kinds of structural models, single input and single output or multiple outputs and multiple inputs and single output, were identified. Differences between the group of fasting pigs and the group of pigs in euglycemic supraphysiological hyperinsulinemia were identified by estimated parameters of the structural models.

The suitability of the structural mathematical models for the estimation of physiologically interpreted parameters from PET was validated.