Are bilateral breast cancers different from breast cancers coexisting with ovarian cancer? An immunohistochemical analysis aimed at intrinsic tumor phenotype

详细信息    查看全文

• 作者：El?bieta Senkus ; Jolanta Szade ; Beata Pieczy¨½ska ; Anna ?aczek ; Izabela Bro?ek ; Barbara Radecka ; Anna Kowalczyk ; Marzena We?nicka-Ja?kiewicz ; Jacek Jassem
• 关键词：Bilateral breast cancer ; Breast-ovarian cancer syndrome ; Intrinsic phenotype ; Immunohistochemistry
• 刊名：The Breast
• 出版年：2013
• 出版时间：August, 2013
• 年：2013
• 卷：22
• 期：4
• 页码：425-430
• 全文大小：223 K

文摘

Rationale

Bilateral breast cancers (BBC) and breast cancers coexisting with ovarian cancer (BOCS) are associated with genetic predisposition more frequently than sporadic cases. We compared the phenotypes of these tumors to better understand their pathomechanisms and aid the guiding of their clinical management.

Materials and methods

Tumor morphology and expression of ER, PgR, HER2, Ki67, CK5/6, E-cadherin, vimentin and EGFR were assessed in a tissue microarray containing cores from 174 BBC, 23 BOCS and 2 BBC?+?BOCS.

Results

BOCS tumors were characterized by higher incidence of EGFR expression, HER2 negativity and lower incidence of intraductal component. HER2-positive phenotypes were marginally more frequent in the BBC group and triple negative tumors - in BOCS.

Conclusion

Breast cancers from BOCS patients are characterized by more aggressive phenotype, most probably related to their more frequent association with BRCA1 mutation.