Disturbances in B- and T-cell homeostasis in rheumatoid arthritis: Suggested relationships with antigen-driven immune responses

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• 作者：Andrea Fekete ; Lilla Soos ; Zoltan Szekanecz ; Zoltan Szabo ; Peter Szodoray ; S ; or Barath ; Gabriella Lakos
• 关键词：Rheumatoid arthritis ; Memory B cells ; Effector memory T cells ; Disease duration ; Antigen-specific immune response
• 刊名：Journal of Autoimmunity
• 出版年：2007
• 出版时间：September-November 2007
• 年：2007
• 卷：29
• 期：2-3
• 页码：154-163
• 全文大小：276 K

文摘

Naïve and memory B- and T-cell subsets were examined with three-color flow cytometry in the peripheral blood of patients with rheumatoid arthritis (RA) in comparison with healthy controls, and their association with disease duration, activity and autoantibodies was investigated in order to reveal potential imprints of antigen-specific immune response in RA. The B-cell population consisted of significantly less naïve (58.1 ± 3.9 % versus 68.7 ± 3.7 % ; p = 0.04), and more IgD−/CD27+ memory B cells (19.6 ± 2.1 % versus 13.7 ± 2.1 % ; p = 0.04) compared to healthy subjects. In addition, strong correlation was demonstrated between disease duration and the percentage of memory B cells (p < 0.0001). Increased CD8+ terminally differentiated effector memory/central memory T-cell ratio (1.35 ± 0.35 versus 0.84 ± 0.24) was also detected in RA patients compared with controls, which also correlated with the duration of RA (p = 0.005). The frequency of memory B cells and CD8+ effector memory T cells correlated with the proportion of CD4+ effector memory lymphocytes, suggesting cooperation between immune cells. Our results reflect disturbances in B- and T-cell homeostasis characterized by the accumulation of memory B cells and a shift towards CD8+ terminally differentiated effector memory T cells in RA, suggesting ongoing, antigen-driven immune response and accelerated differentiation of B and T lymphocytes into effector cells.