Synthesis, X-ray structure and antimycobacterial activity of silver complexes with α-hydroxycarboxylic acids

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• 作者：Alex ; re Cuin ; Antonio C. Massabni ; Clarice Q.F. Leite ; Daisy N. Sato ; Ademir Neves ; Bruno Szpoganicz ; Marlon S. Silva ; Adaí ; lton J. Bortoluzzi
• 关键词：Silver ; Mycobacteria ; α ; -Hydroxycarboxylic acids ; O-donor ligands
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2007
• 出版时间：February 2007
• 年：2007
• 卷：101
• 期：2
• 页码：291-296
• 全文大小：285 K

文摘

In this paper, synthesis, characterization and antimycobacterial properties of a new water-soluble complex identified as silver-mandelate are described. Elemental and thermal analyses are consistent with the formula [Ag(C₆H₅C(OH)COO)]_n. The polymeric structure was determined by single X-ray diffraction and the two-dimensional structure is based on the bis(carboxylate-O,O′) dimer [Ag–O, 2.237(3), 2.222(3) Å]. The structure is extended along both the b and c axes through two oxygen atoms of a bidentate α-hydroxyl-carboxylate residue [Ag–OH(hydroxyl), 2.477(3) Å; Ag–O(carboxylate), 2.502(3) Å; O–Ag–O, 63.94(9)°]. A strong d¹⁰–d¹⁰ interaction was observed between two silver atoms. The AgAg distance is 2.8307(15) Å. The NMR ¹³C spectrum in D₂O shows that coordination of the ligand to Ag(I) occurs through the carboxylate group in solution. Potentiometric titration shows that only species with a molar metal:ligand ratio of 2:2 are formed in aqueous solution. The mandelate complex and the silver-glycolate, silver-malate and silver-hydrogen-tartarate complexes were tested against three types of mycobacteria, Mycobacterium avium, Mycobacterium tuberculosis and Mycobacterium kansasii, and their minimal inhibitory concentration (MIC) values were determined. The results show that the four complexes are potential candidates for antiseptic or disinfectant drugs for discharged secretions of patients affected with tuberculosis.