PTHrP immunoassay results were reviewed over a 12-year period at our institution.
Age, race and gender were not associated with humoral hypercalcemia of malignancy (HHM).
HHM constituted 38% of hypercalcemia among cancer patients.
The prevalence of HHM was lower than previously thought,
Elevated PTHrP was present at initial diagnosis of malignancy in 20% of cases.