P03-303 - Improvement in patient symptoms and functioning during long-term treatment with olanzapine long-acting injection (OLAI)

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• 作者：J. Peuskens¹ ; V. Porsdal² ; J. Pecenak³ ; P. Handest⁴ ; Y. D’ ; yachkova⁵ ; R. Brousil⁶ ; M. Casillas⁷ ; W. Deberdt⁸
• 刊名：European Psychiatry
• 出版年：2011
• 出版时间：2011
• 年：2011
• 卷：26
• 期：supp_S1
• 页码：1473
• 全文大小：1K

文摘

Introduction, objectives and aims

To evaluate the outcome of patients with schizophrenia during maintenance treatment with OLAI.

Methods

Data from three studies with OLAI were pooled and patients classified according to a cluster analysis [Lipkovich, Psychiatry Res, 2009] into five categories according severity of psychiatric symptoms (sx) and functional impairment (imp):

A

(minimal sx/mild imp),

B

(minimal sx/moderate imp),

C

(moderate sx/mild to moderate imp),

D

(moderate sx/severe imp),

E

(moderate to severe sx/severe imp).

Improvement was defined as a change from B or C to A, or from D or E to A, B or C. Changes between the categories in the 6 months were analyzed. Stepwise logistic regression modeling was done to determine factors associated with improvement.

Results

1182 patients were classified. Patients who remained in the studies at 6 months had lower baseline CGI-S (3.04 vs 3.28, p < 0.001), lower PANSS (61.38 vs 64.05, p = 0.012) and higher QLS (1.76 vs 1.39, p = 0.001). (Table 1) As patients in category A couldn¡¯t improve and in category D&E couldn¡¯t worsen, 261(39 % ) patients from categories B, C, D and E improved and only 55(10 % ) from categories A, B and C got worse during 6 months. Baseline factors associated with improvement were: baseline category (p < 0.001), CGI-S score (p = 0.022), and PANSS positive (p = 0.003)

Conclusions

At baseline	Patients in category	PANSS total mean (SD)	QLS total mean (SD)	Classification at 6 (¡À 1) months A	Classification at 6 (¡À 1) months B	Classification at 6 (¡À 1) months C	Classification at 6 (¡À 1) months D	Classification at 6 (¡À 1) months E	6 months drop-outs
A	162 (14 % )	46 (9)	3.9 (1.1)	86	26	7	0	0	34 (21 % )
B	434 (37 % )	55 (11)	0.8 (1.2)	61	210	9	12	1	121 (28 % )
C	208 (18 % )	65 (13)	3.6 (1.2)	68	16	61	8	1	48 (23 % )
D	303 (36 % )	72 (11)	0.6 (10)	14	80	18	62	2	115 (38 % )
E	72 (6 % )	94 (15)	0.5 (0.9)	3	14	3	18	7	21 (29 % )
Total	1182 (100 % )	p < 0.001	p < 0.001	232 (29 % )	346 (44 % )	98 (12 % )	100 (13 % )	11 (1 % )	339