Falsely elevated cyclosporin and tacrolimus concentrations over prolonged periods of time due to reversible adsorption to central venous catheters
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- 作者：Charlotte Hackera ; Mareike Verbeekb ; Heike Schneidera ; Werner Steimera ; steimer-public@klinchem.med.tum.de" class="auth_mail
- 关键词：CsA ; cyclosporine A ; CVC ; central venous catheter ; FFP ; Fresh Frozen Plasma ; P0 ; first 2 ; mL portion of the mimicked in vitro blood sampling (discarded) ; P1&ndash ; P5 ; consecutive 2 ; mL portions of the mimicked in vitro blood sampling ; PU ; polyurethane ; PU-AH-CVC ; PU-In-CVC ; silver-Vy-CVC ; silicone-Vy-CVC ; cf. Table 1 ; Tac ; tacrolimus ; TTP/HUS ; thrombotic thrombocytopenic purpura/hemolytic uremic syndrome
- 刊名：Clinica Chimica Acta
- 出版年：10 June 2014
- 年：2014
- 卷：433
- 期：Complete
- 页码：62-68
- 全文大小：803 K
文摘
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CsA and Tac reversibly adsorb to CVCs causing falsely elevated blood levels.
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All marketable CVC materials are affected (PU, silicone, silver coated).
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Extensive flushing with NaCl or fat emulsion does not stop the drug release.
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Thus, the CVCs remain contaminated for extended periods of time (weeks).
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No cross contamination between different lumina was observed in vitro.