The effects of tACS on spontaneous low frequency fluctuations were evaluated using simultaneous fMRI-tACS.
Electric field simulations were used to predict and evaluate tACS effects relative to directly stimulated regions.
In brain regions exhibiting frequency-dependent effects of tACS, 10 and 40 Hz tACS generally induced opposite effects.
The left fronto-parietal control resting-state network appears to be especially vulnerable to tACS.
Most tACS effects were observed as modulation of functional connectivity between networks.