Homeostatic regulation of germinal stem cell proliferation by the GDNF/FSH pathway

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• 作者：Tadokoro ; Yuko ; Yomogida ; Kentaro ; Ohta ; Hiroshi ; Tohda ; Akira ; Nishimune ; Yoshitake
• 关键词：Germinal stem cell ; Undifferentiated spermatogonia ; Proliferation ; Glial cell line-derived neurotrophic factor ; Follicle-stimulating hormone ; Follicle-stimulating hormone receptor ; Oct-3/4 ; Homeostatic regulation
• 刊名：Mechanisms of Development
• 出版年：2002
• 出版时间：April, 2002
• 年：2002
• 卷：113
• 期：1
• 页码：29-39
• 全文大小：3.10 M

文摘

Stem cell regulatory mechanisms are difficult to study because self-renewal and production of differentiated progeny, which are both strictly controlled, occur simultaneously in these cells. To focus on the self-renewal mechanism alone, we investigated the behavior of germinal stem cells (GSCs) in progeny-deficient testes with defective GSC differentiation. In these testes, we found that the proliferation of undifferentiated spermatogonia, some of which are GSCs, was accelerated by high concentrations of glial cell line-derived neurotrophic factor (GDNF). Furthermore, we found that follicle-stimulating hormone (FSH) stimulation via homeostatic control was one of the major regulators of GDNF concentration. These results suggest that in mammalian testes, GSC proliferation and population size are regulated homeostatically by the GDNF/FSH pathway.