Tetracycline nanoparticles precipitation using supercritical and liquid CO2 as antisolvents
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- 作者：Tae Jun Yoon ; Won-Su Son ; Hee Jeong Park ; Bumjoon Seo ; Taewan Kim ; Youn-Woo Lee ; ywlee@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Precipitation with compressed fluid antisolvent (PCA) ; Nanoparticle ; Coalescence ; Surface diffusion ; Solvent/antisolvent interaction ; Hansen solubility parameter (HSP)
- 刊名：The Journal of Supercritical Fluids
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：107
- 期：Complete
- 页码：51-60
- 全文大小：3816 K
文摘
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We micronized tetracycline using liquid and supercritical CO2 as antisolvent.
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Tetracycline was hypothesized to coalesce following the viscous flow mechanism.
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Effects of process parameters on the coalescence were investigated.
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Precipitates from liquid CO2 were less coalesced than those from supercritical CO2.