Studies directed toward synthesis of taepeenin D: construction of the C4 stereogenic center and the CD benzofuran rings
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- 作者：Yuichiro Nakazawa&dagger ; ; Meri Nagatomo&dagger ; ; Tsuyoshi Oikawa&dagger ; ; Masato Oikawa ; Yuichi Ishikawa ; yu_iskw@yokohama-cu.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hedgehog signaling pathway ; Taepeenin D ; Cyclic ether formation ; Regioselective C&ndash ; C bond formation ; Benzofuran
- 刊名：Tetrahedron Letters
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：57
- 期：24
- 页码：2628-2630
- 全文大小：555 K
文摘
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Taepeenin D is a meroterpenoid isolated from roots and stems of Caesalpinia crista.
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This compound exhibited inhibitory activity of Hedgehog signaling pathway.
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Construction of the quaternary carbon stereogenic center at C4 was accomplished.
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The CD benzofuran rings were selectively constructed in a stepwise manner.
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The D ring was manipulated in 2 steps shorter than that in the previous study.