Investigation of the molecular mechanism of δ-catenin ubiquitination: Implication of β-TrCP-1 as a potential E3 ligase
详细信息 查看全文
- 作者：Hridaya Shresthaa ; 1 ; Tingting Yuana ; 1 ; Yongfeng Hea ; Pyong-Gon Moonb ; Nensi Shresthaa ; Taeyong Ryua ; So-Yeon Parkc ; Young-Chang Chod ; Chan-Hyeong Leeb ; Moon-Chang Baekb ; Sayeon Chod ; Shishli Simkhadaa ; Hangun Kimc ; ; Kwonseop Kima ;
- 关键词：Ubiquitination ; δ-Catenin ; β-TrCP-1
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1863
- 期：9
- 页码：2311-2321
- 全文大小：1673 K
文摘
- •
δ-Catenin can be degraded by both the proteosomal- and the lysosomal pathways.
- •
β-TrCP interacts with δ-catenin and facilitates its degradation via Ub-proteasome.
- •
Ubiquitination sites on δ-catenin are mainly located at its Lys1049 and Lys1158.