Protective effects of physical exercise on MDMA-induced cognitive and mitochondrial impairment
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- 作者：Ghorban Taghizadeha ; Jalal Pourahmadb ; Hajar Mehdizadeha ; Alireza Foroumadic ; Anahita Torkaman-Boutorabia ; Shokoufeh Hassanic ; Parvaneh Naserzadehb ; Reyhaneh Shariatmadarid ; Mahdi Gholamic ; Mohammad Reza Rouinie ; Mohammad Sharifzadeha ; d ; msharifzadeh@sina.tums.ac.ir" class="auth_mail" title="E-mail the corresponding author
- 关键词：MDMA ; 3 ; 4-methylendioxymethamphetamine ; MWM ; Morris water maze test ; ROS ; reactive oxygen species ; MMP ; mitochondrial membrane potential ; IP ; intraperitoneally ; S.C ; subcutaneously ; ETC ; electrone transport chain ; HEPES ; 4-2-hydroxyethyl piperazineethanesulfonic acid ; Rot ; rotenone ; DCFH-DA ; 2&prime ; 7&prime ; -dichlorofluorescein diacetate ; Rh 123 ; Rhodamine 123 ; EGTA ; Ethylene glycol-bis (2-aminoethylether)-N ; N ; N&prime ; N&prime ; -tetraacetic acid ; ANOVA ; analysis of variance
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：11-19
- 全文大小：476 K
文摘
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MDMA administration induces learning and memory impairments.
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MDMA causes mitochondrial dysfunction.
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Physical exercise protects MDMA-induced learning impairments.
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Physical exercise protects MDMA mediated mitochondrial damage by ROS reduction.