Ostertagia ostertagi macrophage migration inhibitory factor is present in all developmental stages and may cross-regulate host functions through interaction with the host receptor
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- 作者：Guanggang Qu<sup>asup><sup> ; sup><sup>bsup> ; Raymond Fetterer<sup>asup> ; Lin Leng<sup>csup> ; Xin Du<sup>csup> ; Dante Zarlenga<sup>asup> ; Zhiqiang Shen<sup>bsup> ; Wenyu Han<sup>dsup> ; Richard Bucala<sup>csup> ; Wenbin Tuo<sup>asup><sup> ; sup><sup>wenbin.tuo@ars.usda.gov" class="auth_mailsup>
- 关键词：Ostertagia ostertagi ; Macrophage migration inhibitory factor ; Oos-MIF ; Cattle ; Nematode
- 刊名：International Journal for Parasitology
- 出版年：May 2014
- 年：2014
- 卷：44
- 期：6
- 页码：355-367
- 全文大小：2474 K
文摘
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Ostertagia ostertagi has three distinctive macrophage migration inhibitory factor (MIF) transcripts (Oos-MIF).
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Oos-MIF-1.1 is localised to hypodermis/muscle, reproductive tract and intestine, but not cuticle.
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Oos-MIF-1 is present in all developmental stages of O. ostertagi.
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rOos-MIF-1.1 has tautomerase, glucocorticoid counter-regulating and macrophage migration inhibitory activities.
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rOos-MIF-1.1 binds to a human MIF receptor and is internalised by macrophages.