Evaluation of dimerization-inhibitory activities of cyclic peptides containing a ¦Â-hairpin loop sequence of the EGF receptor

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• 作者：Takaaki Mizuguchi ; Naho Ohara ; Mika Iida ; Ryunosuke Ninomiya ; Shinji Wada ; Yoshiaki Kiso ; Kazuki Saito ; Kenichi Akaji
• 关键词：EGF receptor ; Dimerization ; Inhibitor ; Cyclic peptide ; Retro-Inverso modification ; A431 cell
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2012
• 出版时间：1 October, 2012
• 年：2012
• 卷：20
• 期：19
• 页码：5730-5737
• 全文大小：840 K

文摘

Structure-activity relationships of cyclic peptides mimicking the ¦Â-hairpin structure of the ¡®dimerization arm¡¯ at residues 242-259 of the EGF receptor are examined. Cyclic peptides containing the arm head of the ¦Â-hairpin loop showed inhibitory activity toward the EGF receptor¡¯s dimerization. Cyclic peptides containing a Retro-Inverso sequence of the dimerization arm showed clear inhibitory effects on the dimerization in vitro and efficiently suppressed the proliferation of A431 cells, which abundantly express the EGF receptor on their surface. The effects at a specific hydrophobic site of the loop structure were expected to enhance the interactions with the receptor.