Elcatonin prevents bone loss caused by skeletal unloading by inhibiting preosteoclast fusion through the unloading-induced high expression of calcitonin receptors in bone marrow cells
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- 作者：Manabu Tsukamoto m-tsuka@med.uoeh-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Kunitaka Menuki menuki@med.uoeh-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Teppei Murai t-murai@med.uoeh-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Akihisa Hatakeyama hatakeakihisa@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Shinichiro Takada behaveabandon@yahoo.co.jp" class="auth_mail" title="E-mail the corresponding author ; Kayoko Furukawa kayoko830@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Akinori Sakai ; a-sakai@med.uoeh-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：CT ; calcitonin ; Calcr ; calcitonin receptor ; QUEST ; Qualitative Effects of Salmon Calcitonin study ; PROOF ; Prevent Recurrence of Osteoporotic Fracture study ; BMD ; bone mineral density ; PTH ; parathyroid hormone ; CGRP ; calcitonin gene related peptide ; TRACP-5b ; tartrate-resistant acid phosphatase-5b ; MNC ; multinucleated cell ; SERM ; selected estrogen receptor modulators ; EL ; elcatonin ; GC ; ground control ; TS ; tail suspension ; Veh ; vehicle ; DXA ; dual-energy X-ray absorption ; pQCT ; peripheral quantita
- 刊名：Bone
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：85
- 期：Complete
- 页码：70-80
- 全文大小：2485 K
文摘
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This is the first description of the effects of elcatonin on unloaded animal bones.
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Elcatonin prevents trabecular bone loss due to unloading in the hindlimbs.
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Unloading increases expression of calcitonin receptors in bone marrow cells.
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Elcatonin suppresses osteoclast development without affecting osteoblast development.
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Elcatonin inhibits differentiation process from preosteoclasts to osteoclasts in vivo.