Successful management of rocuronium-induced anaphylactic reactions with sugammadex: a case report

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• 作者：Takashi Kawano ; MD ; PhD ; ^{takashika@kochi-u.ac.jp} (Associate Professor) ; Takahiko Tamura ; MD (Resident) ; Mayuko Hamaguchi ; MD (Resident) ; Tomoaki Yatabe ; MD (Assistant Professor) ; Koichi Yamashita ; MD ; PhD (Associate Professor) ; Masataka Yokoyama ; MD ; PhD (Professor)
• 关键词：Anesthetics ; anaphylaxis ; Neuromuscular relaxants ; Rocuronium ; anaphylaxis ; Sugammadex
• 刊名：Journal of Clinical Anesthesia
• 出版年：2012
• 出版时间：February 2012
• 年：2012
• 卷：24
• 期：1
• 页码：62-64
• 全文大小：121 K

文摘

Sugammadex, a new reversal agent for rocuronium, encapsulates the rocuronium molecule and results in rapid reversal of rocuronium-induced neuromuscular blockade. A case in which sugammadex was used to treat an anaphylactic reaction that occurred after rocuronium is presented. The binding/encapsulation of rocuronium by sugammadex may selectively eliminate the antigenic quaternary ammonium activity of circulating rocuronium, and prevent the propagation of rocuronium-induced anaphylaxis.