Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation

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• 作者：Etsushi Kuroda¹ ; ² ; ³ ; ^{kuroetu@ifrec.osaka-u.ac.jp} ; Koji Ozasa³ ; ⁴ ; Burcu Temizoz¹ ; Keiichi Ohata¹ ; Christine X. Koo³ ; ⁵ ; ⁶ ; Tomohiro Kanuma¹ ; ³ ; Takato Kusakabe¹ ; ³ ; Shingo Kobari³ ; ⁴ ; Masanori Horie⁷ ; Yasuo Morimoto⁸ ; Saeko Nakajima⁹ ; Kenji Kabashima⁹ ; Steven F. Ziegler¹⁰ ; Yoichiro Iwakura¹¹ ; Wataru Ise¹² ; Tomohiro Kurosaki¹² ; Takahiro Nagatake¹³ ; Jun Kunisawa¹³ ; Naoki Takemura¹⁴ ; ¹⁵ ; Satoshi Uematsu¹⁴ ; ¹⁵ ; Masayuki Hayashi¹ ; ³ ; ¹⁶ ; Taiki Aoshi³ ; ¹⁷ ; Kouji Kobiyama¹ ; ³ ; ¹⁸ ; Cevayir Coban¹⁹ ; Ken J. Ishii¹ ; ² ; ³ ; ^{kenishii@biken.osaka-u.ac.jp}
• 关键词：Particulate ; IL-1α ; alveolar macrophages ; IgE ; iBALT
• 刊名：Immunity
• 出版年：2016
• 出版时间：20 December 2016
• 年：2016
• 卷：45
• 期：6
• 页码：1299-1310
• 全文大小：2946 K
• 卷排序：45

文摘

Particulates act as a long-lasting adjuvant to subsequent antigen inhalation Particulates induce alveolar macrophage death and IL-1α release in the lung IL-1α release in the lung is involved in iBALT formation Tfh cells induced by direct airway sensitization are required for iBALT formation