Influence of Differently Licensed KIR2DL1-Positive Natural Killer Cells in Transplant Recipients with Acute Leukemia: A Japanese National Registry Study
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- 作者：Nobuyoshi Arima1 ; n-arima@kitano-hp.or.jp" class="auth_mail" title="E-mail the corresponding author ; Fumiaki Nakamura2 ; Toshio Yabe3 ; Junji Tanaka4 ; Shigeo Fuji5 ; Kazuteru Ohashi6 ; Takahiro Fukuda5 ; Koichi Miyamura7 ; Koji Iwato8 ; Tetsuya Eto9 ; Takehiko Mori10 ; Naoki Kobayashi11 ; Takumi Hoshino12 ; Chiaki Kato13 ; Heiwa Kanamori14 ; Hirohisa Nakamae15 ; Yoshiko Atsuta16 ; Yasuo Morishima17 ; Yoshinobu Kanda18
- 关键词：Acute leukemia ; Allogeneic hematopoietic stem cell transplantation ; Natural killer cell ; Killer cell immunoglobulin-like receptor ; HLA-C mismatch
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：22
- 期：3
- 页码：423-431
- 全文大小：1217 K
文摘
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National registry enabled this analysis focusing on natural killer cell licensing and leukemia type.
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Distinct susceptibility to donor natural killer cells exists between acute myeloid leukemia and acute lymphoid leukemia.
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Transiently activated C1/C1 NK-cells appeared to target C1/C2 acute myeloid leukemia cells after stem cell transplantation.
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Alloreactivity by natural killer cell may be masked when HLA-C–mismatch exists.
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Donor HLA-C group for KIR2DL impacts on the outcome after HLA-C–mismatched stem cell transplantation.