OVOL2 Maintains the Transcriptional Program of Human Corneal Epithelium by Suppressing Epithelial-to-Mesenchymal Transition
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- 作者：Koji Kitazawa1 ; 2 ; 3 ; 7 ; Takafusa Hikichi1 ; Takahiro Nakamura2 ; 3 ; Kanae Mitsunaga1 ; Azusa Tanaka1 ; Masahiro Nakamura1 ; Tatsuya Yamakawa1 ; Shiori Furukawa1 ; Mieko Takasaka4 ; Naoki Goshima5 ; Akira Watanabe1 ; Keisuke Okita1 ; Satoshi Kawasaki2 ; 6 ; Morio Ueno2 ; Shigeru Kinoshita2 ; 3 ; shigeruk@koto.kpu-m.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Shinji Masui1 ; 7 ; smasui@cira.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：10 May 2016
- 年：2016
- 卷：15
- 期：6
- 页码：1359-1368
- 全文大小：3239 K
文摘
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Identification of a transcription factor that can functionally maintain human CECs
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OVOL2 can activate CEC-specific genes in heterologous cell types
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OVOL2 represses mesenchymal genes in CECs
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EMT may regulate transcriptional programs of surface and neuroectoderm