Association study of fatty acid binding protein 2 gene polymorphism for diabetic nephropathy in Japanese patients with type 2 diabetes

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• 作者：Keiji Yoshioka ; Toshihide Yoshida ; Akinori Kogure ; Yasuto Takakura ; Tsunekazu Umekawa ; Hitoshi Toda
• 关键词：FABP2 gene polymorphism ; Diabetic nephropathy
• 刊名：Diabetes Metabolic Syndrome: Clinical Research Reviews
• 出版年：2010
• 出版时间：January-March 2010
• 年：2010
• 卷：4
• 期：1
• 页码：18-20
• 全文大小：106 K

文摘

To test the hypothesis whether the Ala54Thr polymorphism of the fatty acid binding protein 2 (FABP2) gene was associated with diabetic nephropathy, we studied a total of 397 Japanese type 2 diabetic patients. The diagnosis of diabetic nephropathy was based on measurements of urinary albumin:creatinine ratio (ACR). We subdivided subjects as those with normoalbuminuria (ACR < 30 mg/g Cr), those with micro- albuminuria (ACR:30–300 mg/g Cr), and those with macroalbuminuria (ACR ³300 mg/g Cr). FABP2 genotypes were determined with a fluorescent allele-specific DNA primer assay system. The results showed that the genotypes of Ala54Thr polymorphism of the FABP2 gene were not significantly different among normo-, micro- and macro-albuminuria groups, suggesting that polymorphism of this gene was not associated with diabetic nephropathy in Japanese type 2 diabetic subjects.