Changes in intracortical inhibition and clinical symptoms after STN-DBS in Parkinson’s disease
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- 作者：Masahito Kobayashia ; c ; mkob@saitama-med.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Takayuki Ohirab ; tak@med.keio.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Ban Miharac ; mmh-kenkyu@mihara-ibbv.jp" class="auth_mail" title="E-mail the corresponding author ; Takamitsu Fujimakia ; tfujimak@saitama-med.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Intracortical inhibition ; Parkinson&rsquo ; s disease ; Subthalamic nucleus deep brain stimulation
- 刊名：Clinical Neurophysiology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：127
- 期：4
- 页码：2031-2037
- 全文大小：458 K
文摘
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Deep brain stimulation (DBS) does not restore intracortical inhibition in Parkinson’s disease (PD).
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During DBS-OFF, short-interval intracortical inhibition (SICI), but not silent period, decreases with a similar time course as PD symptoms increase.
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During DBS-OFF, disinhibition of SICI is likely caused by exaggerated short-interval intracortical facilitation.