Association of the triglycerides to high-density lipoprotein cholesterol ratio with the risk of chronic kidney disease: Analysis in a large Japanese population

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• 作者：Kazuhiko Tsuruya ; Hisako Yoshida ; Masaharu Nagata ; Takanari Kitazono ; Hideki Hirakata ; Kunitoshi Iseki ; Toshiki Moriyama ; Kunihiro Yamagata ; Hideaki Yoshida ; Shouichi Fujimoto ; Koichi Asahi ; Issei Kurahashi ; Yasuo Ohashi ; Tsuyoshi Watanabe
• 关键词：Chronic kidney disease ; Diabetes ; Hypertension ; Japanese population ; Triglycerides to high-density lipoprotein cholesterol ratio
• 刊名：Atherosclerosis
• 出版年：March, 2014
• 年：2014
• 卷：233
• 期：1
• 页码：260-267
• 全文大小：390 K

文摘

Objectives

To investigate the relationship between triglycerides to high-density lipoprotein cholesterol ratio (TG/HDL-C) and chronic kidney disease (CKD).

Methods

We used data from 216,007 Japanese adults who participated in a nationwide health checkup program. Men (n聽=聽88,516) and women (n聽=聽127,491) were grouped into quartiles based on their TG/HDL-C levels (<1.26, 1.26-1.98, 1.99-3.18, and >3.18 in men; <0.96, 0.96-1.44, 1.45-2.22, and >2.22 in women). We cross-sectionally assessed the association of TG/HDL-C levels with CKD [defined as an estimated glomerular filtration rate (eGFR) of <60聽mL/min/1.73聽m² (low eGFR) and/or proteinuria (defined as urinary protein 鈮?+ on dipstick testing)], low eGFR, and proteinuria.

Results

The prevalence of CKD, low eGFR, and proteinuria increased significantly with elevating quartiles of TG/HDL-C in both genders (all P for trend <0.001). Participants in the highest quartile of TG/HDL-C had a significantly greater risk of CKD than those in the lowest quartile after adjustment for the relevant confounding factors (odds ratio: 1.57, 95% confidence interval: 1.49-1.65 in men; 1.41, 1.34-1.48 in women, respectively). Furthermore, there were significant associations with low eGFR and proteinuria. In stratified analysis, the risk of CKD increased linearly with greater TG/HDL-C levels in participants with and without hypertension, diabetes, and obesity. Moreover, higher TG/HDL-C levels were relevant for CKD, especially in participants with hypertension and diabetes (P for interaction <0.001, respectively).

Conclusions

An elevated TG/HDL-C is associated with the risk of CKD in the Japanese population.