Pharmacologic stimulation of central GLP-1 receptors has opposite effects on the alterations of plasma FGF21 levels induced by feeding and fasting
详细信息 查看全文
- 作者：Katsunori Nonogaki ; katsu@trc.med.tohoku.ac.jp" class="auth_mail" title="E-mail the corresponding author ; knonogaki-tky@umin.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Takao Kaji ; Tomoe Yamazaki ; Mari Murakami
- 关键词：GLP-1receptor ; Liraglutide ; FGF21 ; Body weight ; Food intake
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：26 January 2016
- 年：2016
- 卷：612
- 期：Complete
- 页码：14-17
- 全文大小：558 K
文摘
- •
Central injection of liraglutide decreased body weight by inhibiting food intake.
- •
Central injection of liraglutide increased plasma FGF21 levels in free-feeding mice.
- •
Central injection of liraglutide reduced plasma FGF21 levels in food-deprived mice.
- •
Liraglutide alters plasma FGF21 levels independently of body weight reduction.
- •
There may be a central feedback system in the regulation of circulating FGF21.