The acute anorexic effect of liraglutide, a GLP-1 receptor agonist, does not require functional leptin receptor, serotonin, and hypothalamic POMC and CART activities in mice
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- 作者：Katsunori Nonogaki ; katsu@trc.med.tohoku.ac.jp" class="auth_mail" title="E-mail the corresponding author ; knonogaki-tky@umin.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Takao Kaji
- 关键词：Liraglutide ; GLP-1 receptor ; POMC ; Orexin ; 5-HT ; Food intake
- 刊名：Diabetes Research and Clinical Practice
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：120
- 期：Complete
- 页码：186-189
- 全文大小：436 K
文摘
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Liraglutide suppressed food intake for 2 h in db/db mice and mice depleted serotonin.
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The acute anorexic effect of liragultide was attenuated in food-restricted KK mice.
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Liraglutide did not affect the expression of hypothalamic POMC, CART or AgRP.
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Liraglutide decreased the expression of hypothalamic orexin in mice.
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The decrease in hypothalamic orexin may contribute to the acute anorexic effect of liragultide.