MIWI2 as an Effector of DNA Methylation and Gene Silencing in Embryonic Male Germ Cells
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- 作者：Kanako Kojima-Kita1 ; Satomi Kuramochi-Miyagawa1 ; 3 ; Ippei Nagamori1 ; Narumi Ogonuki4 ; Atsuo Ogura4 ; Hidetoshi Hasuwa5 ; 7 ; Takashi Akazawa6 ; Norimitsu Inoue6 ; Toru Nakano1 ; 2 ; 3 ; 8 ; tnakano@patho.med.osaka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：13 September 2016
- 年：2016
- 卷：16
- 期：11
- 页码：2819-2828
- 全文大小：2120 K
文摘
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A zinc-finger protein that recognizes the type A LINE-1 retrotransposon was designed
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De novo DNA methylation without piRNAs was induced by the ZF-MIWI2 fusion protein
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ZF-MIWI2 partially rescued impaired spermatogenesis in piRNA-defective mice
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MIWI2 was associated with proteins involved in de novo DNA methylation