Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression
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- 作者：Takuya Kikuchi1 ; Kana Orihara1 ; Fusaka Oikawa1 ; Song-iee Han1 ; Motoko Kuba1 ; Kanako Okuda1 ; Aoi Satoh1 ; Yoshinori Osaki1 ; Yoshinori Takeuchi1 ; Yuichi Aita1 ; Takashi Matsuzaka1 ; Hitoshi Iwasaki1 ; Shigeru Yatoh1 ; Motohiro Sekiya1 ; Naoya Yahagi1 ; Hiroaki Suzuki1 ; Hirohito Sone2 ; Yoshimi Nakagawa1 ; 3 ; ynakagawa@md.tsukuba.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Nobuhiro Yamada1 ; Hitoshi Shimano1 ; 3 ; 4 ; hshimano@md.tsukuba.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：CREBH ; Npc1l1 ; Cholesterol ; Intestine
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：5
- 期：11
- 页码：1092-1102
- 全文大小：1718 K
文摘
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Plasma cholesterol, hepatic lipid, and gallstones were lower in CREBH Tg mice.
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Expression of intestinal Npc1l1 was reduced in CREBH Tg mice.
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CREBH directly down-regulates mouse Npc1l1 promoter activity.
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Intestinal CREBH regulates dietary cholesterol flow from the small intestine.