Dehydroepiandrosterone-enhanced dual specificity protein phosphatase (DDSP) prevents diet-induced and genetic obesity
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- 作者：Tetsuhiro Watanabea ; Kenji Ashidaa ; Kiminobu Gotoa ; Hajime Nawataa ; Ryoichi Takayanagia ; Toshihiko Yanaseb ; Masatoshi Nomuraa ; nomura@med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dehydroepiandrosterone ; DHEA-enhanced dual specificity protein phosphatase ; Obesity ; p38 MAPK ; Leptin
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：4-11 December 2015
- 年：2015
- 卷：468
- 期：1-2
- 页码：196-201
- 全文大小：780 K
文摘
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Mice expressing DHEA-enhanced phosphatase (DDSP-Tg mice) were generated.
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DDSP-Tg mice are resistant to high fat diet-induced obesity.
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DDSP-Tg mice with a db/db background develop a lean and cachexic phenotype.