Single-Fraction Carbon-Ion Radiation Therapy for Patients 80 Years of Age and Older With Stage I Non-Small Cell Lung Cancer

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• 作者：Masataka Karube ; MD^&lowast ; ; ^&dagger ; ; ^{mstk117@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Naoyoshi Yamamoto ; MD ; PhD^&lowast ; ; Mio Nakajima ; MD ; PhD^&lowast ; ; Hideomi Yamashita ; MD ; PhD^&dagger ; ; Keiichi Nakagawa ; MD ; PhD^&dagger ; ; Tadaaki Miyamoto ; MD ; PhD^&lowast ; ; Hiroshi Tsuji ; MD ; PhD^&lowast ; ; Takehiko Fujisawa ; MD ; PhD^&Dagger ; ; Tadashi Kamada ; MD ; PhD^&lowast ;
• 刊名：International Journal of Radiation Oncology*Biology*Physics
• 出版年：2016
• 出版时间：1 May 2016
• 年：2016
• 卷：95
• 期：1
• 页码：542-548
• 全文大小：425 K

文摘

In an aging society, many senior citizens want less invasive treatment because of potential medical complications. The National Institute of Radiological Sciences has started to treat stage I lung cancer with single-fraction carbon-ion radiation therapy (CIRT) as a dose escalation prospective phase 1/2 trial. We evaluated the efficacy and safety of CIRT for patients 80 years of age and older, undergoing single-fraction CIRT.

Methods and Materials

Peripheral non-small cell lung cancer patients who were treated with single-fraction CIRT were prospectively followed. We analyzed the data from among these patients 80 years of age and older.

Results

There were 70 patients. Median age was 83 years (range: 80-89) and median follow-up period was 42.7 months (range: 12-128 months). Three-year local control, cause-specific survival, and overall survival rates were 88.0%, 81.6%, and 72.4%, respectively. Five-year local control, cause-specific survival, and overall survival rates were 85.8%, 64.9%, and 39.7%, respectively. There were no adverse effects higher than grade 2 either in the acute or late phase in terms of skin and lung. Analgesic agents were necessary for only 5 patients (7.1%), to relieve muscular or rib fracture pain caused by irradiation.

Conclusions

Single-fraction CIRT was low-risk and effective, even for the elderly.