Ryanodine receptors contribute to the induction of ischemic tolerance
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- 作者：Emi Nakamura-Maruyamaa ; b ; Osamu Miyamotoa ; Naohiko Okabea ; Naoyuki Himia ; Lu Fenga ; Kazuhiko Naritaa ; Richard F. Keepc ; Tohru Yamamotob ; Takehiro Nakamurab ; tanakamu@kms.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ischemic tolerance ; Ryanodine receptor ; Intracellular Ca2+ ; CA1 hippocampal cells ; Cell culture ; Oxygen glucose deprivation
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：122
- 期：Complete
- 页码：45-53
- 全文大小：2641 K
文摘
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Ryanodine receptor antagonist blocked ischemic tolerance, while a ryanodine receptor agonist stimulated the production of ischemic tolerance.
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Ryanodine receptor antagonists prevented short-term oxygen/glucose deprivation induced preconditioning.
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Ryanodine receptor protein and also mRNA levels decreased after induction of ischemic tolerance.