d-Allose Attenuates Overexpression of Inflammatory Cytokines after Cerebral Ischemia/Reperfusion Injury in Gerbil

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• 作者：Natsuyo Shinohara ; MD^* ; Takehiro Nakamura ; MD ; PhD^&dagger ; ; ^{tanakamu@kms.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Yuko Abe ; MD^* ; Toru Hifumi ; MD^* ; Kenya Kawakita ; MD ; PhD^* ; Aya Shinomiya ; MD ; PhD^&Dagger ; ; Takashi Tamiya ; MD ; PhD^&Dagger ; ; Masaaki Tokuda ; MD ; PhD^§ ; ; Richard F. Keep ; PhD^‖ ; Tohru Yamamoto ; PhD^¶ ; ; Yasuhiro Kuroda ; MD ; PhD^*
• 关键词：Ischemia ; reperfusion ; d-allose ; inflammation ; cytokines ; oxidation ; hyperactivity
• 刊名：Journal of Stroke and Cerebrovascular Diseases
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：25
• 期：9
• 页码：2184-2188
• 全文大小：463 K

文摘

The present study investigates the effects of d-allose, a rare sugar, on the inflammatory response after transient forebrain ischemia in the gerbil and whether it reduces oxidative stress (8-hydroxyl-2′-deoxyguanosine levels) and behavioral deficits.

Methods

Transient forebrain ischemia was induced by occlusion of the bilateral common carotid arteries for 5 minutes. d-Allose was intraperitoneally injected immediately after ischemia (400 mg/kg). Inflammatory cytokines and oxidative damage in the hippocampus and behavioral deficits were examined 3 days after ischemia.

Results

d-Allose administration reduced ischemia-induced cytokine production, oxidative stress, and behavioral deficits (motor and memory related).

Conclusions

The present results suggest that d-allose reduces brain injury after transient global ischemia by suppressing inflammation as well as by inhibiting oxidative stress.