Discovery of an artificial peptide agonist to the fibroblast growth factor receptor 1c/βKlotho complex from random peptide T7 phage display
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- 作者：Kotaro Sakamoto<sup> ; sup><sup>koutarou.sakamoto@takeda.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Yayoi Kawata ; Yasushi Masuda ; Tadashi Umemoto ; Takashi Ito ; Taiji Asami ; Shiro Takekawa ; Tetsuya Ohtaki ; Hiroshi Inooka
- 关键词：Peptide ; Agonist ; FGFR ; βKlotho ; FGF21 ; Phage display
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：4 November 2016
- 年：2016
- 卷：480
- 期：1
- 页码：55-60
- 全文大小：1164 K
文摘
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Artificial peptide agonist to FGFR1c/KLB complex is generated.
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The peptide has no sequence similarity with FGF21.
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The peptide selectively recognizes the complex interface of FGFR1c/βKlotho and activates the it both in vitro and in vivo.