Synthesis and biological activities of reveromycin A and spirofungin A derivatives

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• 作者：Takeshi Shimizu ; Takeo Usui ; Makoto Fujikura ; Makoto Kawatani ; Tomoharu Satoh ; Kiyotaka Machida ; Naoki Kanoh ; Je-Tae Woo ; Hiroyuki Osada ; Mikiko Sodeoka
• 关键词：Reveromycin A ; Spirofungin A ; Isoleucyl-tRNA synthetase ; Osteoclasts ; src^ts-NRK cells
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2008
• 出版时间：1 July 2008
• 年：2008
• 卷：18
• 期：13
• 页码：3756-3760
• 全文大小：206 K

文摘

Various derivatives of reveromycin A, an inhibitor of eukaryotic cell growth, and spirofungin A, focusing on the 5S hydroxyl group and C18 hemisuccinyl group, were synthesized and their inhibitory effects on both the isoleucyl-tRNA synthetase activity and the survival of osteoclasts, and activities on the morphological reversion of src^ts-NRK cells were examined. It was found that 2,3-dihydroreveromycin A is the promising derivative of reveromycin A based on the activity and stability.