A cysteine protease from Spirometra erinaceieuropaei plerocercoid is a critical factor for host tissue invasion and migration

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• 作者：Daigo Tsubokawa^a ; ^b ; Takeshi Hatta^a ; ^b ; Hiroki Maeda^b ; ^d ; Fusako Mikami^b ; Yukinobu Goso^c ; Takeshi Nakamura^b ; M. Abdul Alim^e ; Naotoshi Tsuji^a ; ^b ; ^{tsujin@med.kitasato-u.ac.jp}
• 关键词：Spirometra erinaceieuropaei ; Plerocercoid ; Cysteine protease ; Body dissolution ; Invasion ; Migration
• 刊名：Acta Tropica
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：167
• 期：Complete
• 页码：99-107
• 全文大小：1903 K
• 卷排序：167

文摘

A cysteine protease (Se23kCP) is purified from S. erinaceieuropaei plerocercoids. Se23kCP has both cysteine and serine protease-specific activities. Se23kCP is secreted from tegumental vacuoles and degrades host structural proteins. The body region of plerocercoid is lysed by Se23kCP, allowing host tissue invasion. Se23kCP acts for host tissue invasion and migration of plerocercoid.