A Factor Affecting Enantioselective Reaction of A Ternary Complex of Lithium Ester Enolate with Imine

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• 作者：Kambara ; Takeshi ; Hussein ; Mostafa Ahmed ; Fujieda ; Hiroki ; Iida ; Akira ; Tomioka ; Kiyoshi
• 刊名：Tetrahedron Letters
• 出版年：1998
• 出版时间：December 3, 1998
• 年：1998
• 卷：39
• 期：49
• 页码：9055-9058
• 全文大小：176 K

文摘

Systematic investigation of the varying size of the alkoxy moiety of the lithium ester enolates in the chiral ligand mediated reaction with imines led to the improvement of the enantioselectivity of β-lactam products in up to 93 % . The asymmetric induction step was indicated to be the addition step, not the cyclization step.