DJ-1 activates SIRT1 through its direct binding to SIRT1
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- 作者：Kazuko Takahashi-Nikia ; Yoko Ganahaa ; Takeshi Nikib ; Shota Nakagawaa ; Izumi Kato-Osea ; Sanae M.M. Iguchi-Arigab ; Hiroyoshi Arigaa ; hiro@pharm.hokudai.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：DJ-1 ; SIRT1 ; Deacetylase ; p53
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：20 May 2016
- 年：2016
- 卷：474
- 期：1
- 页码：131-136
- 全文大小：848 K
文摘
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DJ-1 binds to SIRT1, 2 and 4–6 in a C106 of DJ-1-dependent manner.
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DJ-1 enhances lysine deacetylase activity of SIRT1.
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DJ-1 inhibits p53 activity through SIRT1.
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SIRT1 activity is reduced in DJ-1-knockout cells, and its reduced activity is restored by re-introduction of DJ-1.