Histone H2A T120 Phosphorylation Promotes Oncogenic Transformation via Upregulation of Cyclin D1
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- 作者：Hitoshi Aihara1 ; 10 ; Takeya Nakagawa1 ; 10 ; Hirofumi Mizusaki1 ; 10 ; Mitsuhiro Yoneda1 ; Masanori Kato1 ; Masamichi Doiguchi1 ; Yuko Imamura1 ; Miki Higashi1 ; Tsuyoshi Ikura2 ; Tomonori Hayashi3 ; Yoshiaki Kodama3 ; Masaya Oki1 ; Toshiyuki Nakayama1 ; Edwin Cheung4 ; Hiroyuki Aburatani5 ; Ken-ichi Takayama6 ; 7 ; Haruhiko Koseki8 ; Satoshi Inoue6 ; 7 ; Yukio Takeshima9 ; Takashi Ito1 ; 11 ; tito@nagasaki-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：phosphorylation ; ubiquitylation ; histone modification ; VRK1 ; cyclin D1 ; NHK-1 ; H2A
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：6 October 2016
- 年：2016
- 卷：64
- 期：1
- 页码：176-188
- 全文大小：4107 K
文摘
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hVRK1 phosphorylates histone H2A T120 in and around promoter regions
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H2A pT120 and H2A K119 ubiquitylation are mutually antagonistic
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H2A pT120 regulates transcription by affecting histone H3 K4 methylation
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The H2A T120D mutation mimics phosphorylation and promotes oncogenic transformation