Conversion of Terminally Committed Hepatocytes to Culturable Bipotent Progenitor Cells with Regenerative Capacity

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• 作者：Takeshi Katsuda¹ ; Masaki Kawamata¹ ; ² ; Keitaro Hagiwara¹ ; Ryou-u Takahashi¹ ; Yusuke Yamamoto¹ ; Fernando D. Camargo² ; Takahiro Ochiya¹ ; ³ ; ^{tochiya@ncc.go.jp}
• 关键词：liver progenitor cell ; in vitro reprogramming ; liver repopulation ; small molecule ; bipotentiality
• 刊名：Cell Stem Cell
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：20
• 期：1
• 页码：41-55
• 全文大小：6589 K
• 卷排序：20

文摘

A chemical cocktail converts rodent hepatocytes into proliferative cells in vitro Chemically converted cells, named CLiPs, are bipotent CLiPs can be stably cultured without obvious phenotypic alterations CLiPs repopulate chronically injured liver tissues with an efficiency of 75%–90%