Glyceraldehyde-3-phosphate dehydrogenase aggregation inhibitor peptide: A potential therapeutic strategy against oxidative stress-induced cell death
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- 作者：Masanori Itakura1 ; Hidemitsu Nakajima ; 1 ; hnakajima@vet.osakafu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yuko Semi ; Shusaku Higashida ; Yasu-Taka Azuma ; Tadayoshi Takeuchi
- 关键词：GAPDH ; Protein aggregation ; Inhibitor ; Cell death ; Therapeutics
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：13 November 2015
- 年：2015
- 卷：467
- 期：2
- 页码：373-376
- 全文大小：446 K
文摘
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We developed a GAPDH aggregation inhibitor (GAI) peptide.
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The GAI peptide inhibits GAPDH aggregation in a concentration-dependent manner.
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The GAI peptide does not affect GAPDH enzyme activity or cell viability.
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The GAI peptide shows a protective effect against oxidative stress-induced cell death.
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We produced a novel tool to study oxidative stress-induced disorders.