Heat stress promotes the down-regulation of IRE1α in cells: An atypical modulation of the UPR pathway
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- 作者：Takujiro Homma ; Junichi Fujii ; jfujii@med.id.yamagata-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：ATF6 ; activating transcription factor-6 ; CHX ; cycloheximide ; eIF2α ; phospho-eukaryotic initiation factor 2α ; ER ; endoplasmic reticulum ; ERAD ; ER-associated degradation ; IRE1α ; inositol-requiring protein-1α ; MEF ; mouse embryonic fibroblast ; PDI ; protein disulfide isomerase ; PERK ; dsRNA-activated protein kinase-like ER kinase ; Prx4 ; peroxiredoxin 4 ; UPR ; unfolded protein response ; XBP-1 ; X-box binding protein-1
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：349
- 期：1
- 页码：128-138
- 全文大小：1897 K
文摘
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Heat stress effectively activated all branches of the UPR in cells.
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The IRE1α protein to only protein to be downregulated by heat stress.
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Inhibiting the autophagic process partially restored the levels of IRE1α.
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The downregulation of IRE1α might function as a negative feedback system of UPR.