Photoactive ligands probing the sweet taste receptor. Design and synthesis of highly potent diazirinyl d-phenylalanine derivatives
详细信息 查看全文
- 作者：Katsuyoshi Masuda ; Ayako Koizumi ; Takumi Misaka ; Yasumaru Hatanaka ; Keiko Abe ; Takaharu Tanaka ; Masaji Ishiguro ; Makoto Hashimoto
- 关键词：Sweet taste ; d-Amino acid ; Photoaffinity label ; Diazirine
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2010
- 出版时间：1 February 2010
- 年：2010
- 卷：20
- 期：3
- 页码：1081-1083
- 全文大小：329 K
文摘
Some d-Amino acids such as d-tryptophan and d-phenylalanine are well known as naturally-occurring sweeteners. Photoreactive d-phenylalanine derivatives containing trifluoromethyldiazirinyl moiety at 3- or 4-position of phenylalanine, were designed as sweeteners for functional analysis with photoaffinity labeling. The trifluoromethyldiazirinyl d-phenylalanine derivatives were prepared effectively with chemo-enzymatic methods using l-amino acid oxidase and were found to have potent activity toward the human sweet taste receptor.