MiR-27b is epigenetically downregulated in tamoxifen resistant breast cancer cells due to promoter methylation and regulates tamoxifen sensitivity by targeting HMGB3
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- 作者：Xiunan Li ; Yumei Wu ; yumeiwu1@163.com" class="auth_mail" title="E-mail the corresponding author ; Aihui Liu ; Xin Tang
- 关键词：MiR-27b ; Promoter methylation ; Tamoxifen ; HMGB3
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：2 September 2016
- 年：2016
- 卷：477
- 期：4
- 页码：768-773
- 全文大小：1331 K
文摘
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MiR-27b downregulation in TamR cells is a result of promoter methylation.
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Enforced miR-27b expression sensitizes TamR cells to tamoxifen.
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Enforced miR-27b expression inhibits cell invasion and reverses EMT.
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MiR-27b directly targets HMGB3 in breast cancer cells.
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Silencing of HMGB3 phenocopies the effects of miR-27b in TamR cells.