Hyrtimomines, indole alkaloids from Okinawan marine sponges Hyrtios spp.

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• 作者：Naonobu Tanaka ; Rei Momose ; Azusa Takahashi-Nakaguchi ; Tohru Gonoi ; Jane Fromont ; Jun'ichi Kobayashi
• 关键词：Indole alkaloids ; Marine sponge ; Hyrtios spp. ; Hyrtimomines
• 刊名：Tetrahedron
• 出版年：28 January, 2014
• 年：2014
• 卷：70
• 期：4
• 页码：832-837
• 全文大小：532 K

文摘

Six new indole alkaloids, hyrtimomines F-K (1-6), were isolated from Okinawan marine sponges Hyrtios spp. The structures of 1-6 were elucidated on the basis of spectroscopic analysis. Hyrtimomine F (1) is a structurally unique bisindole alkaloid possessing an 伪-keto-蓻-caprolactam ring, while hyrtimomine G (2) is a symmetrical bisindole alkaloid. Hyrtimomines H-K (3-6) are indole alkaloids possessing 尾-carboline skeleton with an imidazolium unit. Antimicrobial activities of hyrtimomines F-K (1-6) were evaluated.