Embryonic expression of mSharp-1/mDEC2, which encodes a basic helix–loop–helix transcription factor
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- 作者：Azmi ; Sameena ; Taneja ; Reshma
- 关键词：Adrenal gland ; Basic helix&ndash ; loop&ndash ; helix protein ; Branchial arch ; Eye ; Hairy/Enhancer of Split ; Heart ; Limb bud ; Liver ; Mouse embryogenesis ; Nervous system ; Notch signaling ; Olfactory epithelium ; Prevertebra ; Sensory ganglia ; Thyroid gland ; Thymu
- 刊名：Mechanisms of Development
- 出版年：2002
- 出版时间：June, 2002
- 年：2002
- 卷：114
- 期：1-2
- 页码：181-185
- 全文大小：338 K
文摘
We describe the expression pattern of mouse Sharp-1 (mSharp-1), a member of the basic helix–loop–helix (bHLH) family of transcription factors. mSharp-1 belongs to the Hairy/Enhancer of Split (E(Spl)) subfamily of bHLH factors that are key targets of the Notch signaling pathway and exhibits the highest sequence identity with Stra13. RNA in situ hybridization analysis from embryonic day 7.5 (E7.5) to E16.5 revealed specific expression of mSharp-1 in several developing organs during mouse embryogenesis. In early stage embryos (E8.5–E12.5), mSharp-1 is expressed in specific dorsal regions of the developing brain, the heart, the developing eye and olfactory system, as well as in the limb buds. At later stages (E12.5-E16.5), mSharp-1 is also expressed in the liver, prevertebrae, and the developing adrenal and thyroid glands. The diversity of its expression pattern suggests that mSharp-1 may regulate the differentiation of several cell types during vertebrate development.