Synthesis of α,α-difluoro-β-hydroxy ketone via the La(OTf)3-catalyzed aldol reaction of carbonyl compounds with difluoroenol O-Boc esters
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- 作者：Shigeru Sasaki ; s-sasaki@hoshi.ac.jp ; Tatuo Suzuki ; Toshihiro Uchiya ; Shigenobu Toyota ; Akira Hirano ; Mao Tanemura ; Hiroyoshi Teramoto ; Takayasu Yamauchi ; Kimio Higashiyama
- 关键词：Aldol reaction ; Difluoroenol O-Boc ester ; α ; α-Difluoro-β-hydroxy ketone ; lyzed reaction
- 刊名：Journal of Fluorine Chemistry
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：192
- 期：part_PA
- 页码：78-85
- 全文大小：503 K
- 卷排序：192
文摘
An efficient method for the preparation of α,α-difluoro-β-hydroxy ketones in good yield is reported. Carbonyl compounds were reacted with difluoroenol O-Boc ester in the La(OTf)3-catalyzed aldol reaction. The difluoroenol O-Boc esters are easily synthesized from trifluoromethyl alcohols in two steps. The difluoromethylene moiety can be introduced to a range of carbonyl compound in short reaction times. This process should be applicable in biochemical, biomedical, and pharmaceutical research.