Efficacy and safety of Yunxiangjing derived from Chinese herbal medicine administered as an enema in the management of acute radiation-induced proctitis in patients with pelvic malignancy

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• 作者：Tang Huaying^a ; Huang Yinchun^a ; Mo Xingneng^a ; Yi Guisheng^b ; Wen Hui^b ; Guo Zhen^a ; Feng Kaihua^a ; Liu Yin^c ; Bu Qing^d ; Jiang Wei^a ; ^{weijiang@glmc.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Pelvic neoplasms ; Radiation ; Proctitis ; Drugs ; Chinese herbal ; Enema ; Yunxiangjing
• 刊名：Journal of Traditional Chinese Medicine
• 出版年：2016
• 出版时间：15 February 2016
• 年：2016
• 卷：36
• 期：1
• 页码：45-50
• 全文大小：552 K

文摘

To assess the efficacy and safety of Yunxiangjing (YXJ), derived from Chinese herbal medicine, in the management of acute radiation-induced proctitis (ARIP) in patients with pelvic malignancy.

Methods

Forty-eight patients with grade 2 ARIP were administered YXJ as an enema (1:30 dilution) for 2 weeks and followed up for 2 years. All were assessed for response and ARIP grade. Quality of life (QOL) was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30.

Results

Of the 48 patients, six (12.5%) achieved complete remission of ARIP and 28 (58.3%) showed a decrease from grade 2 to grade 1 ARIP. No patient experienced a grade ≥3 toxicity. At the end of radiotherapy, patients showed significant improvements in QOL (P < 0.05). Two years after treatment, 46 patients showed no late toxicity, with only two experiencing grade 1 late toxicity.

Conclusion

YXJ can be used as an enema to manage acute radiation-induced proctitis in cancer patients undergoing radiotherapy. These findings suggest that YXJ enema may be an alternative treatment of ARIP.