Mapping and Role of the CD8⁺ T Cell Response During Primary Zika Virus Infection in Mice

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• 作者：Annie Elong Ngono¹ ; Edward A. Vizcarra¹ ; William W. Tang¹ ; Nicholas Sheets¹ ; Yunichel Joo¹ ; Kenneth Kim¹ ; Matthew J. Gorman² ; Michael S. Diamond² ; Sujan Shresta¹ ; ³ ; ^{sujan@lji.org}
• 关键词：Zika virus ; CD8+ T cell ; epitope ; peptide ; mouse model ; LysMCre+IFNARfl/fl
• 刊名：Cell Host & Microbe
• 出版年：2017
• 出版时间：11 January 2017
• 年：2017
• 卷：21
• 期：1
• 页码：35-46
• 全文大小：2422 K
• 卷排序：21

文摘

LysMCre+IFNARfl/fl mice developed as a model to investigate T cell responses to ZIKV ZIKV infection elicits CD8+ T cells targeting viral PrM, E, and NS5 proteins in mice ZIKV-immune CD8+ T cell transfer reduced while depletion increased viral burdens in mice CD8−/− mice displayed higher mortality with ZIKV infection