Biomimetic nanochannels based biosensor for ultrasensitive and label-free detection of nucleic acids
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- 作者：Zhongyue Suna ; 1 ; Tangbin Liaoa ; 1 ; Yulin Zhanga ; Jing Shub ; Hong Zhangc ; redguo@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Guo-Jun Zhanga ; zhanggj@hbtcm.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nanochannels ; Biosensor ; Label-free detection ; DNA ; Hybridization
- 刊名：Biosensors and Bioelectronics
- 出版年：2016
- 出版时间：15 December 2016
- 年：2016
- 卷：86
- 期：Complete
- 页码：194-201
- 全文大小：1284 K
文摘
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3-D nanochannel-based biosensor for DNA detection has been proposed.
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DNA-DNA hybridization has been employed to realize label-free and sensitive detection of DNA by using fabricated nanochannel.
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The fabricated nanochannel is able to detect DNA in interfering system and serum sample.
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High sensitivity has been achieved based on this detection system.
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The developed sensing platform shows good sequence discrimination.