Investigation of single-pass tangential flow filtration (SPTFF) as an inline concentration step for cell culture harvest

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• 作者：Abhiram Arunkumar ; Nripen Singh ; ^{nripen.singh@bms.com} ; Michael Peck ; Michael C. Borys ; Zheng Jian Li
• 关键词：Single pass tangential flow filtration ; Ultrafiltration ; Concentration ; Cell culture harvest ; Debottlenecking
• 刊名：Journal of Membrane Science
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：524
• 期：Complete
• 页码：20-32
• 全文大小：1439 K
• 卷排序：524

文摘

First to demonstrate challenges in using SPTFF for harvest concentration. Novel strategy to overcome challenges during harvest concentration using SPTFF. First to demonstrate impact of adsorptive filtration on SPTFF performance. First to demonstrate coupling of SPTFF with primary clarification. Data for debottlenecking using SPTFF presented for 6 biologic assets.